Development and in Vitro Evaluation of Tizanidine hydrochloride Buccal Tablet using Tamarind Seed Gum

An endeavor has been made to create buccoadhesive bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing recurrence. Tablets of Tizanidine hydrochloride were prepared by direct compression method using bioadhesive polymer tamarind seed gum with backing layer of ethyl cellulose. The physical characteristics, swelling index, surface pH, in vitro bioadhesion strength, and in vitro release of formulated tablets were shown to be obsessed with characteristics and composition of bioadhesive materials used. The modified in vitro assembly was used to measure and compare the bioadhesive strength of tablets with fresh intestinal mucosa of rabbits as a model tissue. The maximum bioadhesive strength was observed in tablets formulated with 50% tamarind seed gum and strength decreases with decrease in its content. The tablets were evaluated for in vitro release in pH 6.8 phosphate buffer. In order to determine the mode of release, the data was subjected to Korsmeyer and Peppas model. All the formulations followed non-Fickian release mechanism. Tamarind seed gum could be used to design viable and stable buccoadhesive tablets of Tizanidine hydrochloride.